It may be that the serpent bloodline has nothing to do with Satan or Lucifer, but represents the first humanoids to follow Eve and may even share some of her DNA as perhaps cousins or as that which brought them to life. In some ancient texts, there is a distinction made between multiple women/goddesses and only one is referred to as having a womb so any children attributed to Eve (the virgin queen or “goddess”) would be adopted or claimed by her-much like the Lost Boys in Peter Pan. Lost Boys may also be a reference to the Lost Tribes.
However, python is also slang for penis. This would imply that the Python (also possibly the Witch of Endor) was actually a male and the serpent line comes from them.